Body’s Susceptibility to Infection Influenced by Time of DayThe time of day may have a major influence on a person’s susceptibility to infection, according to a study published in Proceedings of the National Academy of Sciences and reported in Becker’s Infection Control & Clinical Quality (August 16). Researchers infected mice with the herpes virus at different times of day and monitored infection levels. They found the amount of virus replication was 10 times greater in mice infected at the beginning of their active periods compared with those infected 10 hours later. “The time of day of infection can have a major influence on how susceptible we are to the disease, or at least on the viral replication, meaning that infection at the wrong time of day could cause a much more severe acute infection,” said the study’s senior author Akhilesh Reddy, PhD, a researcher at the Wellcome Trust-Medical Research Council Institute of Metabolic Science at University of Cambridge. “This is consistent with recent studies which have shown that the time of day that the influenza vaccine is administered can influence how effectively it works.”
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